Title: Analysis of 90 patients treated with or without long-term epirubicin plus Ara-C intravesical instillation therapy for low-grade superficial bladder cancer: a case control study
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چکیده
Background: The high incidence of tumor recurrence following transurethral resection (TUR) continues to represent a major problem encountered in the treatment of bladder cancer. This study examined the limited efficacy of intravesical chemotherapy in superficial bladder cancer. Methods: Subjects comprised 90 cases with low-grade superficial transitional cell carcinoma who were rendered tumor-free by TURBT (TUR of bladder tumor) and then treated with or without intravesical chemotherapy. Instillation was terminated due to adverse effects in 2 patients treated with intravesical chemotherapy and excluded from further analysis. The remaining 88 patients were divided into 2 groups according to therapy: the TURBT-only group (n=46), defined as patients treated with TURBT alone; and the Instillation group (n=42), defined as patients treated with long-term and intensive intravesical instillation therapies using epirubicin plus Ara-C. Results: Recurrence-free rate was significantly higher in the Instillation group than in the TURBT-only group (p=0.045). The 5-year recurrence-free rate was 58.5% for the Instillation group and 38.6% for the TURBT-only group. Recurrence-history, tumor-grade, tumor-multiplicity and instillation-therapy were identified as independent prognostic factors for local recurrence (p=0.007, 0.012, 0.036 and 0.457 respectively). Conclusions: Our instillation schedule represents the most intensive regimen among
منابع مشابه
Analysis of Japanese Patients Treated with or without Long-Term Epirubicin Plus Ara-C Intravesical Instillation Therapy for Low-Grade Superficial Bladder Cancer
The high incidence of tumor recurrence following transurethral resection (TUR) represents a major problem encountered in the management of bladder cancer. This study examined the efficacy of intravesical chemotherapy in superficial bladder cancer. We retrospectively analyzed 90 Japanese cases with low-grade superficial transitional cell carcinoma (stage T1, grades 1 and 2) who were rendered tum...
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تاریخ انتشار 2010